Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons
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چکیده
منابع مشابه
Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress
BACKGROUND Sex-related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure. However, whether similar differences are seen in iron-overload cardiomyopathy is poorly understood. METHODS AND RESULTS Male and female wild-type and hemojuvelin-null mice we...
متن کاملIron-Induced Damage in Cardiomyopathy: Oxidative-Dependent and Independent Mechanisms
The high incidence of cardiomyopathy in patients with hemosiderosis, particularly in transfusional iron overload, strongly indicates that iron accumulation in the heart plays a major role in the process leading to heart failure. In this context, iron-mediated generation of noxious reactive oxygen species is believed to be the most important pathogenetic mechanism determining cardiomyocyte damag...
متن کاملIRON METABOLISM Iron overload and chelation
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form...
متن کاملprotective effects of crocin against streptozotocin-induced oxidative damage in rat striatum.
the study aimed to investigate the protective effects of crocin (cro) against streptozotocin (stz)-induced oxidative damage in rat striatum. animals were randomly divided into four groups (five each). group 1 (sham) were treated with normal saline (2 ml/kg, p.o.). group 2 (stz-lesioned or lesion) were injected with icv-stz (3 mg/kg bilaterally, on day 1 and 3) and treated with normal saline (2 ...
متن کاملAluminum taken up by transferrin-independent iron uptake affects the iron metabolism in rat cortical cells.
We previously demonstrated that cultured human fibroblasts internalize iron via transferrin-independent iron uptake (Tf-IU), redox, and receptor-mediated endocytosis uptake systems [Oshiro, S., Nakajima, H., Markello, T., Krasnewich, D., Bernardini, I., and Gahl, W.A. (1993) J. Biol. Chem. 268, 21586 21591]. Of these iron transport systems, the Tf-IU system is involved in the accumulation of tr...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2016
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2016.78